Early Probe and Drug Discovery in Academia: A Minireview
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چکیده
منابع مشابه
Early Probe and Drug Discovery in Academia: A Minireview
Drug discovery encompasses processes ranging from target selection and validation to the selection of a development candidate. While comprehensive drug discovery work flows are implemented predominantly in the big pharma domain, early discovery focus in academia serves to identify probe molecules that can serve as tools to study targets or pathways. Despite differences in the ultimate goals of ...
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It has become clear in recent years that multiple signal transduction pathways are employed upon GPCR activation. One of the major cellular effectors activated by GPCRs is extracellular signal-regulated kinase (ERK). Both G-protein and β-arrestin mediated signaling pathways can lead to ERK activation. However, depending on activation pathway, the subcellular destination of activated ERK1/2 may ...
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ژورنال
عنوان ژورنال: High-Throughput
سال: 2018
ISSN: 2571-5135
DOI: 10.3390/ht7010004